Angiotensin Converting Enzyme Insertion/Deletion Polymorphism and Renoprotection in Diabetic and Nondiabetic Nephropathies

Angiotensin converting enzyme insertion/deletion polymorphism and renoprotection in diabetic and nondiabetic nephropathies.

Despite the huge amount of studies looking for candidate genes, the ACE gene remains the unique, well-characterized locus clearly associated with pathogenesis and progression of chronic kidney disease, and with response to treatment with drugs that directly interfere with the renin angiotensin system (RAS), such as angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor antag...

Angiotensin-converting enzyme inhibition and angiotensin II antagonism in nondiabetic chronic nephropathies.

Angiotensin II (A II), the main effector of the renin angiotensin system (RAS), plays a central role in the hemodynamic and nonhemodynamic mechanisms of chronic renal disease and is currently the main target of interventions aimed to prevent the onset and progression of chronic nephropathies to end-stage renal disease (ESRD). In addition, to ameliorate glomerular hyperfiltration and size select...

Angiotensin Converting Enzyme in Sarcoidosis

polymorphism in the angiotensin-converting enzyme (ace) gene and ace activity in type 2 diabetic patients

diabetes mellitus is a multifactorial disease. it has recently been shown that an insertion (i)/deletion (d) polymorphism exists in the angiotensin-converting enzyme (ace) gene that can affect the serum ace level. there are three genotypes: dd, di, and ii, with the ace level being highest in dd, intermediate in di, and lowest in ii. in the present investigation, 170 patients with type 2 diabete...

Angiotensin-converting Enzyme Genetic Polymorphism

Indeed, the sample size limitation is a universal bias in all of the genetic polymorphisms in heart failure and the ACE-genotype was no different. The metanalysis by Bai et al.1. with 17 different studies included 2.453 cases (i.e. heart failure patients) from all over the world with only 60.3% being white individuals. The author concluded that there was no association between ACE DD genotype a...